(BUTTON) LIFE ____________________ (BUTTON) Search Search SIGN IN Subscribe First TakeLarry Fink's Take on the Dignity of Photography Larry Fink White HouseWhite House Tells Dissenters in State Department: 'Get With the Program' or Quit White House Press Secretary Sean Spicer answers questions during the daily press briefing at the White House, January 30, 2017 in Washington, DC. Barack ObamaBarack Obama Praises Protests Against President Trump's Immigration Ban: 'American Values Are at Stake' President Obama Holds Year-End Press Conference WorldThe History of Walls Is Long. Here's Where Donald Trump Fits In GERMANY-US-POLITICS-INAUGURATION-DEMO Heroin addicts, New York, photographed by Bill Eppridge VIEW GALLERY | 9 PHOTOS Caption from LIFE. Her arms around Johnny and his brother, Bro -- also an addict -- Karen lies hopelessly on a hotel bed.Bill Eppridge—The LIFE Picture Collection/Getty Images Heroin addicts, New York, photographed by Bill Eppridge Needle Park, LIFE magazine, Feb. 26, 1965 Needle Park, LIFE magazine, Feb. 26, 1965 Needle Park, LIFE magazine, Feb. 26, 1965 Needle Park, LIFE magazine, Feb. 26, 1965 Needle Park, LIFE magazine, Feb. 26, 1965 Needle Park, LIFE magazine, Feb. 26, 1965 Needle Park, LIFE magazine, Feb. 26, 1965 Needle Park, LIFE magazine, Feb. 26, 1965 Caption from LIFE. Her arms around Johnny and his brother, Bro -- also an addict -- Karen lies hopelessly on a hotel bed. ... VIEW MORE 1 of 9 LIFE Photo Essay 'Two Lives Lost to Heroin': A Harrowing, Early Portrait of Addicts Ben Cosgrove Updated: Mar 04, 2015 2:48 PM UTC | Originally published: Oct 03, 2013 'We are animals in a world no one knows' In February 1965, LIFE magazine published an extraordinary photo essay on two New York City heroin addicts, John and Karen. Photographed by Bill Eppridge, the pictures — and the accompanying article, reported and written by LIFE associate editor James Mills — were part of a two-part series on narcotics in the United States. A sensitive, clear-eyed and harrowing chronicle of, as LIFE phrased it, "two lives lost to heroin," Eppridge's pictures shocked the magazine's readers and brought the sordid, grim reality of addiction into countless American living rooms. To this day, Eppridge's photo essay remains among the most admired and, for some, among the most controversial that LIFE ever published. His pictures and Mills' reporting, meanwhile, formed the basis for the 1971 movie, Panic in Needle Park, which starred Al Pacino and Kitty Winn as addicts whose lives spin inexorably out of control. Here, on the heels of the sobering news that heroin-related deaths quadrupled in the U.S. in the last three years, LIFE.com presents Eppridge's "Needle Park" photo essay in its entirety, as it appeared in LIFE — a portrait of two young people who have become, as they themselves put it, "animals in a world no one knows." [See more of Bill Eppridge's work.] Customer ServiceSite MapPrivacy PolicyAd ChoicesTerms of UseYour California Privacy RightsCareers © 2017 Time Inc. All rights reserved. All products and services featured are based solely on editorial selection. TIME may receive compensation for some links to products and services on this website. SIGN IN SUBSCRIBE ____________________ (BUTTON) Search Home U.S. Politics World Business Tech Health Motto Entertainment Science Newsfeed Living Sports History The TIME Vault Magazine Ideas Parents TIME Labs Money LIFE The Daily Cut Photography Videos TIME Shop Press Room The 100 Most Influential People The 25 Best Inventions of 2015 Future of Giving Global Trade Know Right Now Next Generation Leaders Person of the Year 2015 Top 10 Everything of 2015 Top of the World A Year In Space Subscribe Newsletters Feedback Privacy Policy Your California Privacy Rights Terms of Use Ad Choices RSS TIME Apps TIME for Kids Advertising Reprints and Permissions Site Map Help Customer Service Follow TIME SHARE Share on Facebook Post on Twitter Email this story Share on Reddit Share on Pinterest Share on LinkedIn