312- measured in the subjects of our high self-assessment group occurred 313: earlier in the day than the peak of the daily rhythm measured in a 314- previous study [[91]15]. Peak hormonal secretions often shift to the -- 328- Thus, a subject's pattern of melatonin secretion may reflect his or her 329: life rhythm, and melatonin secretion appears to be an important index 330- of circadian rhythmicity. Based on our previous finding that growth -- 439- 17. Nagane M, Yoshimura K, Watanabe SI, Nomura M: Examination of the 440: validity of growth hormone as an index of the biological rhythm in 441- comparison with cortisol and melatonin in Japanese healthy